We profiled microglia using single-cell multi-omics techniques in lymphoma-bearing mice and patients who developed neurotoxicity after CAR19 T cell transfer. We discovered that microglial activation after CAR19 T cell infusion was mediated mainly by the kinase TAK1, which suggests that targeting TAK1 in patients receiving CAR19 T cell-based cancer immunotherapy could treat neurotoxicity.
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References
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This is a summary of: Vinnakota, J. M. et al. Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome. Nat. Cancer https://doi.org/10.1038/s43018-024-00764-7 (2024).
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Targeting TAK1 in microglia to treat CAR T cell neurotoxicity. Nat Cancer (2024). https://doi.org/10.1038/s43018-024-00765-6
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DOI: https://doi.org/10.1038/s43018-024-00765-6
